Arsenic-containing fatty acids and hydrocarbons in marine oils - determination using reversed-phase HPLC-ICP-MS and HPLC-qTOF-MS.
Identifieur interne : 000241 ( Main/Exploration ); précédent : 000240; suivant : 000242Arsenic-containing fatty acids and hydrocarbons in marine oils - determination using reversed-phase HPLC-ICP-MS and HPLC-qTOF-MS.
Auteurs : RBID : pubmed:24607114Abstract
Arsenolipids are the major arsenic species present in marine oils. Several structures of arsenolipids have been elucidated the last 5 years, demonstrating the chemical complexity of this trace element in the marine environment. Several commercial fish oils and marine oils, ranging in total arsenic concentrations from 1.6 to 12.5 mg kg(-1) oil, were analyzed for arsenolipids using reversed-phase high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). The arsenolipids were quantified using three different arsenic-containing calibration standards; dimethylarsinate (DMA), triphenylarsinoxide (Ph₃AsO) and a synthesized arsenic-containing hydrocarbon (AsHC) (dimethylarsinoyl nonadecane; C₂₁H₄₃AsO). The observed variation in signal intensity for arsenic during the gradient elution profile in reversed-phase HPLC was compensated for by determining the time-resolved response factors for the arsenolipids. Isotopes of germanium ((74)Ge) and indium ((115)In) were suited as internal standards for arsenic, and were used for verification of the arsenic signal response factors during the gradient elution. Dimethylarsinate was the most suitable calibration standard for the quantification of arsenolipids, with recoveries between 91% and 104% compared to total arsenic measurements in the same extracts. A range of marine oils was investigated, including oils of several fish species, cod liver and seal, as well as three commercial fish oils. The AsHCs - C₁₇H₃₈AsO, C₁₉H₄₂AsO and C₂₃H₃₈AsO - were identified as the major arsenolipids in the extracts of all oils by HPLC coupled with quadrupole time-of-flight mass spectrometry (qTOF-MS). Minor amounts of two arsenic-containing fatty acids (AsFAs) (C₂₃H₃₈AsO₃ and C₂₄H₃₈AsO₃) were also detected in the oils. The sum of the AsHCs and the AsFAs determined in the present study accounted for 17-42% of the total arsenic in the oils.
DOI: 10.1016/j.talanta.2013.12.049
PubMed: 24607114
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Arsenic-containing fatty acids and hydrocarbons in marine oils - determination using reversed-phase HPLC-ICP-MS and HPLC-qTOF-MS.</title><author><name sortKey="Sele, Veronika" uniqKey="Sele V">Veronika Sele</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway; Institute of Biology, University of Bergen, Post Box 7803, N-5020 Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway; Institute of Biology, University of Bergen, Post Box 7803, N-5020 Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Sloth, Jens J" uniqKey="Sloth J">Jens J Sloth</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway; National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway; National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg</wicri:regionArea></affiliation></author><author><name sortKey="Holmelid, Bjarte" uniqKey="Holmelid B">Bjarte Holmelid</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, University of Bergen, Post Box 7803, N-5020 Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Chemistry, University of Bergen, Post Box 7803, N-5020 Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Valdersnes, Stig" uniqKey="Valdersnes S">Stig Valdersnes</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen</wicri:regionArea></affiliation></author><author><name sortKey="Skov, Kasper" uniqKey="Skov K">Kasper Skov</name><affiliation wicri:level="1"><nlm:affiliation>National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg</wicri:regionArea></affiliation></author><author><name sortKey="Amlund, Heidi" uniqKey="Amlund H">Heidi Amlund</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway. Electronic address: Heidi.Amlund@nifes.no.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><date when="2014">2014</date><idno type="doi">10.1016/j.talanta.2013.12.049</idno><idno type="RBID">pubmed:24607114</idno><idno type="pmid">24607114</idno><idno type="wicri:Area/Main/Corpus">000129</idno><idno type="wicri:Area/Main/Curation">000129</idno><idno type="wicri:Area/Main/Exploration">000241</idno></publicationStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Arsenolipids are the major arsenic species present in marine oils. Several structures of arsenolipids have been elucidated the last 5 years, demonstrating the chemical complexity of this trace element in the marine environment. Several commercial fish oils and marine oils, ranging in total arsenic concentrations from 1.6 to 12.5 mg kg(-1) oil, were analyzed for arsenolipids using reversed-phase high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). The arsenolipids were quantified using three different arsenic-containing calibration standards; dimethylarsinate (DMA), triphenylarsinoxide (Ph₃AsO) and a synthesized arsenic-containing hydrocarbon (AsHC) (dimethylarsinoyl nonadecane; C₂₁H₄₃AsO). The observed variation in signal intensity for arsenic during the gradient elution profile in reversed-phase HPLC was compensated for by determining the time-resolved response factors for the arsenolipids. Isotopes of germanium ((74)Ge) and indium ((115)In) were suited as internal standards for arsenic, and were used for verification of the arsenic signal response factors during the gradient elution. Dimethylarsinate was the most suitable calibration standard for the quantification of arsenolipids, with recoveries between 91% and 104% compared to total arsenic measurements in the same extracts. A range of marine oils was investigated, including oils of several fish species, cod liver and seal, as well as three commercial fish oils. The AsHCs - C₁₇H₃₈AsO, C₁₉H₄₂AsO and C₂₃H₃₈AsO - were identified as the major arsenolipids in the extracts of all oils by HPLC coupled with quadrupole time-of-flight mass spectrometry (qTOF-MS). Minor amounts of two arsenic-containing fatty acids (AsFAs) (C₂₃H₃₈AsO₃ and C₂₄H₃₈AsO₃) were also detected in the oils. The sum of the AsHCs and the AsFAs determined in the present study accounted for 17-42% of the total arsenic in the oils.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Process"><PMID Version="1">24607114</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>10</Day></DateCreated><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-3573</ISSN><JournalIssue CitedMedium="Internet"><Volume>121</Volume><PubDate><Year>2014</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Talanta</Title><ISOAbbreviation>Talanta</ISOAbbreviation></Journal><ArticleTitle>Arsenic-containing fatty acids and hydrocarbons in marine oils - determination using reversed-phase HPLC-ICP-MS and HPLC-qTOF-MS.</ArticleTitle><Pagination><MedlinePgn>89-96</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.talanta.2013.12.049</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0039-9140(13)01042-4</ELocationID><Abstract><AbstractText>Arsenolipids are the major arsenic species present in marine oils. Several structures of arsenolipids have been elucidated the last 5 years, demonstrating the chemical complexity of this trace element in the marine environment. Several commercial fish oils and marine oils, ranging in total arsenic concentrations from 1.6 to 12.5 mg kg(-1) oil, were analyzed for arsenolipids using reversed-phase high performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). The arsenolipids were quantified using three different arsenic-containing calibration standards; dimethylarsinate (DMA), triphenylarsinoxide (Ph₃AsO) and a synthesized arsenic-containing hydrocarbon (AsHC) (dimethylarsinoyl nonadecane; C₂₁H₄₃AsO). The observed variation in signal intensity for arsenic during the gradient elution profile in reversed-phase HPLC was compensated for by determining the time-resolved response factors for the arsenolipids. Isotopes of germanium ((74)Ge) and indium ((115)In) were suited as internal standards for arsenic, and were used for verification of the arsenic signal response factors during the gradient elution. Dimethylarsinate was the most suitable calibration standard for the quantification of arsenolipids, with recoveries between 91% and 104% compared to total arsenic measurements in the same extracts. A range of marine oils was investigated, including oils of several fish species, cod liver and seal, as well as three commercial fish oils. The AsHCs - C₁₇H₃₈AsO, C₁₉H₄₂AsO and C₂₃H₃₈AsO - were identified as the major arsenolipids in the extracts of all oils by HPLC coupled with quadrupole time-of-flight mass spectrometry (qTOF-MS). Minor amounts of two arsenic-containing fatty acids (AsFAs) (C₂₃H₃₈AsO₃ and C₂₄H₃₈AsO₃) were also detected in the oils. The sum of the AsHCs and the AsFAs determined in the present study accounted for 17-42% of the total arsenic in the oils.</AbstractText><CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sele</LastName><ForeName>Veronika</ForeName><Initials>V</Initials><Affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway; Institute of Biology, University of Bergen, Post Box 7803, N-5020 Bergen, Norway.</Affiliation></Author><Author ValidYN="Y"><LastName>Sloth</LastName><ForeName>Jens J</ForeName><Initials>JJ</Initials><Affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway; National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.</Affiliation></Author><Author ValidYN="Y"><LastName>Holmelid</LastName><ForeName>Bjarte</ForeName><Initials>B</Initials><Affiliation>Department of Chemistry, University of Bergen, Post Box 7803, N-5020 Bergen, Norway.</Affiliation></Author><Author ValidYN="Y"><LastName>Valdersnes</LastName><ForeName>Stig</ForeName><Initials>S</Initials><Affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway.</Affiliation></Author><Author ValidYN="Y"><LastName>Skov</LastName><ForeName>Kasper</ForeName><Initials>K</Initials><Affiliation>National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.</Affiliation></Author><Author ValidYN="Y"><LastName>Amlund</LastName><ForeName>Heidi</ForeName><Initials>H</Initials><Affiliation>National Institute of Nutrition and Seafood Research, Post Box 2029, Nordnes, N-5817 Bergen, Norway. Electronic address: Heidi.Amlund@nifes.no.</Affiliation></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>12</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Talanta</MedlineTA><NlmUniqueID>2984816R</NlmUniqueID><ISSNLinking>0039-9140</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Arsenic</Keyword><Keyword MajorTopicYN="N">Arsenolipids</Keyword><Keyword MajorTopicYN="N">HPLC–ICP-MS</Keyword><Keyword MajorTopicYN="N">HPLC–qTOF-MS</Keyword><Keyword MajorTopicYN="N">Marine oils</Keyword><Keyword MajorTopicYN="N">Speciation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>9</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>12</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>12</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>12</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>3</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0039-9140(13)01042-4</ArticleId><ArticleId IdType="doi">10.1016/j.talanta.2013.12.049</ArticleId><ArticleId IdType="pubmed">24607114</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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